Recently, there has been a growing use of bile acids and their derivatives as absorption enhancers for drug delivery. Due to their high solubility, bile acid derivatives act as emulsifying agents and drug carriers in the form of mixed micelles, bilosomes and chemical conjugates with drug molecules. Sodium glycocholate and Glycocholic acid, together with soy phosphatidylcholine, have frequently been used in mixed micelles dosage forms for intravenous administration. The role of bile acid derivatives in promoting drug permeation has been experimentally illustrated in various pharmaceutical formulations. Applications include oral, nasal, occular, pulmonary and rectal drug delivery, as well as parenteral techniques to overcome the blood-brain-barrier. VIO Chemicals offers Sodium glycocholate and Glycocholic acid as advanced bile acid components for robust drug formulation and delivery.
FEATURES
Excellent biocompatibility
Natural emulsifying ability
Amphiphilicity
High aqueous solubility
BENEFITS
The use of mixed micelles of bile acids as solubilizers has great benefits for drug formulation and delivery:
They are biocompatible
They are available in parenteral quality
They are easy to manufacture
They are natural components of the blood
And, unlike synthetic solubilizers, they do not bear any risks for anaphylactic reactions.
APPLICATIONS
Mixed micelles formulations based on Sodium glycocholate or Glycocholic acid are used in several injectable products to solubilize poorly water soluble drug substances for intravenous administration, such as Konakion MM®, Rycarfa®, Cernevit®, Phosphogliv® and many more.
Products which are subject to patent protection are currently not offered or made available in countries where patents are in force.
No orders or deliveries are possible prior to the expiry date of valid patents.