CAS No: 1370705-39-7
Bicyclo[1.1.1]pentanes are novel chemical tools for bioisosteric replacement of aromatic and lipophilic groups. Bicyclo[1.1.1]pentanes are rigid scaffolds with one or two exit vectors positioned in a linear manner, thereby mimicking the para substitution pattern on arenes or tert-butyl/lipophilic moieties. Monosubstituted Bicyclo-[1.1.1]pentanes can also serve as surrogates for tert-butyl/lipophilic moieties.
For high-quality Bicyclo[1.1.1]pentanes at commercial scale, VIO Chemicals collaborates with SpiroChem, the world leader in the design and synthesis of Bicyclo[1.1.1]pentanes. SpiroChem’s novel and proprietary synthetic pathways evolve into cost -efficient manufacturing processes, which allow for largescale production of a broad range of bicyclo- [1.1.1]pentanes. In this collaboration, SpiroChem undertakes route scouting, small-scale lab synthesis and route optimisation, while VIO Chemicals performs process optimisation, technology transfer to its facilities in China and commercial scale manufacturing.
Bicyclo[1.1.1]pentanes are excellent chemical tools for bioisosteric replacement of aromatic groups. Due to their three-dimensional fragments, they possess equivalent or improved physico-chemical and pharmaco-kinetic properties compared to the moieties they are replacing. Especially when an arene group serves as a spacer/scaffold and it is not involved in -interactions with the biological target, switching to the corresponding Bicyclo- [1.1.1]pentane is strongly advised. Bicyclo[1.1.1]- pentanes are highly recommended to medicinal chemists not only for their improved properties but also for the chemical diversity and novel IP space that they offer.
Bicyclo[1.1.1]pentanes are commonly used in drug discovery programs and the demand for these building blocks is growing exponentially.
Want to have regular news and product updates sent to your inbox?
Simply fill in your email address below and press subscribe.
You can easily unsubscribe at anytime and your email address will not be given to any third party.