Trehalose: the remarkable “sugar of life”
Trehalose, also known as the “sugar of life” or “resurrection sugar”, is associated with the survival of several organisms that live under extreme environmental conditions.
It is a naturally occurring disaccharide comprised of two molecules of glucose. It is present in a variety of organisms such as bacteria, yeast, fungi, insects, invertebrates animals, and lower and higher plants, which synthesize it as a source of energy and use it to survive from freezing and lack of water.
Trehalose was isolated in the mid-19th century by the French chemist Marcellin Berthelot. Since then, there has been extensive research on the biological and chemical properties of trehalose and its role in living organisms.
Functions of trehalose
One of the most interesting characteristics of trehalose, known as anhydrobiosis, refers to the fact that many living organisms synthesize this unique sugar as a response to prolonged periods of desiccation . The production of large quantities of trehalose may contribute to the survival of the living organism, even when it has lost more than 99% of its water .
Trehalose acts as a protectant for lipid bilayers by maintaining the lipid in a liquid phase during absence of water. Lipid bilayers (or phospholipid bilayer) are thin polar membranes that form a physical barrier between the cell and its environment. They require a degree of hydration to maintain their integrity, otherwise desiccation could result to irreversible damage of the cell .
Trehalose also protects labile cellular proteins against damage and denaturation caused by desiccation and oxidative stress. The ability of trehalose to stabilize and protect protein molecules has been exploited in biopharmaceutical formulations.
Applications of trehalose
Trehalose is widely used in the food industry, acting as a safe preservative by inhibiting the degradation of carbohydrates, proteins, and fatty acids in foods.
It is also used in cosmetics, functioning as a moisturizer, skin protectant and antioxidant.
Trehalose is a new entry in the pharmaceutical toolbox. It is applied in the biopharmaceutical industry to stabilise proteins, lipids, and carbohydrates, in the preservation of labile protein drugs and the cryopreservation of human cells.
Current studies investigate several other medical applications including the treatment of various neurodegenerative diseases, such as Parkinson, Huntington’s chorea and Alzheimer’s disease.
What we offer
We offer high quality low endotoxin and GMO-free Trehalose dihydrate and Trehalose anhydrous, for pharmaceutical and cosmetic applications, at competitive prices.
- Stick, R., Williams, S., (2010). Carbohydrates: The Essential Molecules of Life. Elsevier Science.
- Stolz, J., Luyckx, & Baudouin, C. (2011). Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology, Clinical Ophthalmology, 577, DOI:10.2147/opth.s18827